Publications

Research Articles

Key Publications

Khandaker GM, Oltean BP, Kaser M, Dibben CRM, Ramana R, Jadon, DR, Dantzer R, Coles AJ, Lewis G, Jones PB (2018). Protocol for the insight study: a randomised controlled trial of single- dose tocilizumab in patients with depression and low-grade inflammation . BMJ Open, 8:1-9 doi: 10.1136/bmjopen-2018-025333   (PubMed)

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All Publications

Foley ÉM, Slaney C, Donnelly NA, Kaser M, Ziegler L, Khandaker GM. (2024).   A novel biomaker of interleukin 6 activity and clinical cognitive outcomes in depression.  Psychoneuroendocrinology 164, 107008. doi  10.1016/j.psyneuen.2024.107008 ( PubMed)

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Claybourne ZM, Zou R, Gilman SE, Khandaker GM, Fell DB, Colman I, El Marroun H (2023). Associations between prenatal maternal stress, maternal inflammation during pregnancy, and children's internalizing and externalizing symptoms through childhood . Brain Behav Immun. 2023. Nov;114:165-172. doi:1.1016/j.bbi.2023.08.017. Epub 2023 Aug. PMID: 37607663 (PubMed)

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Arrunda AL, Khandaker GM, Morris AP, Smith GD, Huckins LM, Zeggini E. (2023)  Genomic insights into the comorbidity between type 2 diabetes and schizophrenia . medRxiv. 2023 Oct 16:2023.10.16.23297073. doi: 10.1101/2023.10.16.23297073. Preprint. PMID: 37905000 (PubMed)

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Clayborne ZM, Nilsen W, Torvik FA, Gustavson K, Bekkhus M, Gilman SE, Khandaker GM, Fell DB, Colman I. (2023)  Positive maternal mental health attenuates the associations between prenatal stress and children's internalizing and externalizing symptoms.  Eur Child Adolesc Psychiatry. 2023 Sep;32(9):1781-1794. doi: 10.1007/s00787-022-01999-4. Epub 2022 May 14. PMID: 35567646 ( PubMed)

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Crick DCP, Sanderson E, Jones H, Goulding N, Borges MC, Clayton G, Carter AR, Halligan S, Lawlor DA, Khandaker GM, Fraser A. (2023)   Glycoprotein acetyls and depression: Testing for directionality and potential causality using longitudinal data and Mendelian randomization analyses.   J Affect Disord. 2023 Aug 15;335:431-439. doi: 10.1016/j.jad.2023.05.033. Epub 2023 May 15. PMID: 37196932 (PubMed )

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Slaney C, Sallis HM, Jones HJ, Dardani C; Charge Inflammation Working Group; Tilling K, Munafò MR, Davey Smith G, Mahedy L, Khandaker GM.(2023)  Association between inflammation and cognition: Triangulation of evidence using a population-based cohort and Mendelian randomization analyses.   Brain Behav Immun. 2023 May;110:30-42. doi: 10.1016/j.bbi.2023.02.010. Epub 2023 Feb 13. PMID: 36791891 (PubMed)

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Stochl J, Jones H, Soneson E, Wagner AP, Khandaker GM, Zammit S, Heron J, Hammerton G, Bullmore ET, Dolan R, Fonagy P, Goodyer IM, Perez J, Jones PB. (2023)   Stratification of adolescents across mental phenomena emphasizes the importance of transdiagnostic distress: a replication in two general population cohorts.   Eur Child Adolesc Psychiatry. 2023 May;32(5):797-807. doi: 10.1007/s00787-021-01909-0. Epub 2021 Nov 18. PMID: 34792650 (PubMed)

 

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Clayborne ZM, Nilsen W, Torvik FA, Gustavson K, Bekkhus M, Gilman SE, Khandaker GM, Fell DB, Colman I.  (2023)  Prenatal maternal stress, child internalizing and externalizing symptoms, and the moderating role of parenting: findings from the Norwegian mother, father, and child cohort study.  Psychol Med. 2023 Apr;53(6):2437-2447. doi: 10.1017/S0033291721004311. Epub 2021 Nov 25. PMID: 37310302 (PubMed)  

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Foley ÉM, Khandaker GM  . (2023)  Cytokines in psychosis: from mechanism towards treatment and prediction.   Lancet Psychiatry. 2023 Apr;10(4):237-239. doi: 10.1016/S2215-0366(23)00056-1. Epub 2023 Feb 27. PMID: 36863382 No abstract available. (PubMed)

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Foley ÉM, Griffiths SL, Murray A, Rogers J, Corsi-Zuelli F, Hickinbotham H, Warwick E, Wilson M, Kaser M, Murray GK, Deakin B, Jadon D, Suckling J, Barnes NM, Upthegrove R, Khandaker GM; (2023)  Protocol for the Psychosis Immune Mechanism Stratified Medicine (PIMS) trial: a randomised double-blind placebo-controlled trial of single-dose tocilizumab in patients with psychosis. PIMS Collaboration.   BMJ Open. 2023 Mar 24;13(3):e067944. doi: 10.1136/bmjopen-2022-067944. PMID: 36963796 Clinical Trial. (PubMed)

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Manderson JL, Smoll NR, Krenske DL, Nedwich L, Harbin L, Charles MG, Wyatt A, Schulz CN, Walker J, Khandaker GM. (2023)  SMS reminders increase on-time vaccination in Aboriginal and Torres Strait Islander infants .  Commun Dis Intell (2018). 2023 Mar 23;47. doi: 10.33321/cdi.2023.47.13. PMID: 36958928 (PubMed)

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Foley ÉM, Parkinson JT, Mitchell RE, Turner L, Khandaker GM. (2023)  Peripheral blood cellular immunophenotype in despression: a systemactic review and meta-analysis. Mol Psychiatry. 2023 Mar;28(3):1004-1019. doi:10.1038/s41380-022-01919-7. Epub 2022 Dec 28. PMID: 36577838  (PubMed) 

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Chaplin AB, Daniels NF, Pies D, Anderson RZ, Gregory-Jones A, Jones PB, Khandaker GM (2023) Longitudinal association between cardiovascular risk factors and despression in young people: a systemactic review and meta-analysis of cohort studies.  Psychol Med. 2023 Feb;53(3):1049-1059. doi: 10.1017/S0033291721002488. Epub 2021 Jun 25. PMID: 34167604 (PubMed)

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Hamilton FW, Thomas M, Arnold D, Palmer T, Moran E, Mentzer AJ, Maskell N, Baillie K, Summers C, Hingorani A, MacGowan A, Khandaker GM, Mitchell R, Davey Smith G, Ghazal P, Timpson NJ. (2023)  Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study.   PLoS Med. 2023 Jan 30;20(1):e1004174. doi: 10.1371/journal.pmed.1004174. eCollection 2023 Jan. PMID: 36716318 (PubMed)

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Osimo EF, Perry BI, Mallikarjun P, Pritchard M, Lewis J, Katunda A, Murray GK, Perez J, Jones PB, Cardinal RN, Howes OD, Upthegrove R, Khandaker GM. (2023)  Predicting treatment resistance from first-episode psychosis using routinely collected clinical information. Nat Ment Health.  2023 Jan 19;1(1):25-35. doi: 10.1038/s44220-022-00001-z. PMID: 37034013 (PubMed)  

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Edmondson-Stait AJ, Shen X, Adams MJ, Barbu MC, Jones HJ, Miron VE, Allardyce J, Boardman JP, Lawrie SM, McIntosh AM, Khandaker GM, Kwong ASF, Whalley HC. (2022)  Early-life inflammatory markers and subsequent psychotic and depressive episodes between 10 to 28 years of age.   Brain Behav Immun Health. 2022 Oct 10;26:100528. doi:  10.1016/j.bbih.2022.100528. eCollection 2022 Dec. PMID: 36277463  (PubMed)

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Perry BI, Vandenberghe F, Garrido-Torres N, Osimo EF, Piras M, Vazquez-Bourgon J, Upthegrove R, Grosu C, De La Foz VO, Jones PB, Laaboub N, Ruiz-Veguilla M, Stochl J, Dubath C, Canal-Rivero M, Mallikarjun P, Delacrétaz A, Ansermot N, Fernandez-Egea E, Crettol S, Gamma F, Plessen KJ, Conus P, Khandaker GM, Murray GK, EAP CB, Crespo-Facorro B. (2022)  The psychosis metabolic risk calculator (PsyMetRic) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples. Lancet Reg Health Eur. 2022 Aug 19;22:100493. dio 10.1016/j.lanepe.2022.100493. eCollection 2022 Nov PMID: 36039146 (PubMed)

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Galan D, Perry BI, Warrier V, Davidson CC, Stupart O, Easton D, Khandaker GM, Murray GK. (2022)  Applying Mendelian randomization to appraise causality in relationships between smoking, depression and inflammation . Sci Rep. 2022 Sep 3;12(1):15041. doi: 10.1038/s41598-022-19214-4. PMID: 36057695 (PubMed)

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Osimo EF, Lewis J, Cardinal RN, Khandaker GM. (2022)  Clozapine treatment and risk of COVID-19 . BJPsych Open. 2022 Jul 11;8(4):e131. doi 10.1192/bjo.2022.537. PMID: 35815763 (PubMed)

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Sadik A, Dardani C, Pagoni P, Havdahl A, Stergiakouli E; iPSYCH Autism Spectrum Disorder Working Group; Khandaker GM, Sullivan SA, Zammit S, Jones HJ, Davey Smith G, Dalman C, Karlsson H, Gardner RM, Rai D. (2022)  Parental inflammatory bowel disease and autism in children.   Nat Med. 2022 Jul;28(7):1406-1411. doi: 10.1038/s41591-022-01845-9. Epub 2022 Jun 2. PMID: 35654906 (PubMed)

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Williams JA, Burgess S, Suckling J, Lalousis PA, Batool F, Griffiths SL, Palmer E, Karwath A, Barsky A, Gkoutos GV, Wood S, Barnes NM, David AS, Donohoe G, Neill JC, Deakin B, Khandaker GM, Upthegrove R; (2022)  Inflammation and brain structure in schizophrenia and other neuropsychiatric disorders: A mendelian randomization study. PIMS Collaboration . JAMA Psychiatry. 2022 May 1;79(5):498-507. doi:10.1001/jamapsychiatry.2022.0407. PMID:35353173 (PubMed) 

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Donnelly NA, Perry BI, Jones HJ, Khandaker GM. (2022)  Childhood immuno-metabolic markers and risk of depression and psychosis in adulthood: a propsective birth cohort study. Psychoneuroendocrinology. 2022 May; 139:105707. doi:101.1016/j.psyneuen.2022.105707. Epub 0222 Feb 26. PMID: 35286909 (PubMed)

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Milaneschi Y, Kappelmann N, Ye Z, Lamers F, Moser S, Jones PB, Burgess S, Penninx BWJH, Khandaker GM. (2022) Correction: Association of inflammation with depression and eanziety: evidence for sympton-specificity and potential causality from UK Biobank and NESDA cohorts. Mol Psychiatry. 2022 Mar; 27(3):1856. doi:10.1038/s41380-021-01388-4. PMID: 34785785 (PubMed)

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Perry BI, Bowker N, Burgess S, wareham NJ, Upthegrove R, Jones PB, Langenberg C, Khandaker GM. (2022) Evidence for Shared Genetic Aetiology Between Schizophrenia, Cardiometabolic and Inflammation-related Traits: Geneitc Correlation and Colocalisation Analyses. Schizophr Bull Open. 2022 Jan 11;3(1):sgac001. doi: 10.1093/schizbullopen/sgac001. eCollection 2022 Jan. PMID: 35156041 (PubMed)

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Crick DCP, Halligan SL, Howe LD, Lacey RE, Khandaker GM, Burgner D, Herbert A, Suderman M, Anderson EL, Fraser A. (2022)  Associations between Adverse Childhood Experiences and the novel inflammatory marker gylcoprotein acetyls in two generations of the Avon Longitudinal Study of Parents and Children birth cohort.  Brain Behav Immun. 2022 Feb;100:112-120.0 doi. 10.1016/j.bbi.2021.11.001. Epub 2021 Nov 15. PMID:34793940 (PubMed)

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Kaser M, Foley ÉM, Khandaker GM. (2021)  Neurocognitive Performance in Depressed Ptients with low-grade inflammation and somatic symptons.  Brain Behav Immun Health. 2021 Dec 24;19:100409. doi:10.10.16/j.bbih.2021.100409. eCollection 2022 Feb. PMID:35036964 (PubMed)

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Kapplemann N, Perry BI, Khandaker GM (2022) Prenatal and Childhood Immuno-Metabolic Risk Factors for Adult Depression and Psychosis Harvard Review of Psychiatry 01;30(1):8-23  (PubMed)

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Perry BI, Bowker N, Burgess S, Wareham NJ, Upthegrove R, Jones PB, Langenberg C, Khandaker GM. (2022) Evidence for Shared Genetic Aetiology Between Schizophrenia, Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization Analyses. Schizophr Bull Open. 3(1):sgac001. doi: 10.1093/schizbullopen/sgac001.  (PubMed)

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Kappelmann N, Arloth J, Georgakis MK, Czamara D, Rost N, Ligthart S, Khandaker GM, Binder EB (2021) Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study  jamapsychiatry.2020.3436  (PubMed)

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Kapplemann N, Dantzer R, Khandaker GM (2021) Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19 Psychoneuroendocrinology 131:105295  (PubMed)

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Chu AL, Hickman M, Steel N, Jones PB, Davey Smith G, Khandaker GM (2021) Inflammation and Depression: A Public Health Perspective Brain Behaviour and Immunity 95:1-3  (PubMed)

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Perry B, Osimo EF, Khandaker GM (2021) Risk Prediction in Psychosis: Progress Made and Challenges Ahead  Biological Psychiatry 90(9):590-592  (PubMed)

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Chaplin AB, Jones PB, Khandaker GM (2021) Sexual and physical abuse and depressive symptoms in the UK Biobank BMC Psychiatry 21(1):248  (PubMed)

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Kaser M, Foley ÉM, Khandaker GM (2021) Neurocognitive Performance in Depressed Patients with low-grade inflammation and somatic symptoms  Brain, Behaviour and Immunity 19:100409  (PubMed)

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Kappelmann N, Czamara D, Rost N, Moser S, Schmoll V, Trastulla L, Stochl J, Lucae S, Binder EB, Khandaker GM, Arloth J (2021) Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study Brain, Behaviour and Immunity 95:256-268  (PubMed)

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Chaplin AB, Jones PB, Khandaker GM (2021) Sexual and physical abuse and depressive symptoms in the UK Biobank . BMC Psychiatry 21(1):248. doi: 10.1186/s12888-021-03207-0.  (PubMed)

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Foley ÉM, Parkinson JT, Kappelmann N, Khandaker GM (2021) Clinical phenotypes of depressed patients with evidence of inflammation and somatic symptoms. Compr Psychoneuroendocrinol. 8:100079. doi: 10.1016/j.cpnec.2021.100079.  (PubMed)

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MacKenzie G, Subramaniam S, Caldwell LJ, Fitzgerald D, Harrison NA, Hong S, Irani SR, Khandaker GM, Liston A, Miron VE, Mondelli V, Morgan BP, Pariante C, Shah DK, Taams LS, Teeling JL, Upthegrove R. (2021) Research priorities for neuroimmunology: identifying the key research questions to be addressed by 2030 . (PubMed) Wellcome Open Res. 6:194. doi: 10.12688/wellcomeopenres.16997.1. 

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Perry BI, Upthegrove R, Kappelmann N, Jones PB, Burgess S, Khandaker GM. (2021) Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian randomization study. Brain Behav Immun. 97:176-185. doi: 10.1016/j.bbi.2021.07.009.  (PubMed)

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Milaneschi Y, Kappelmann N, Ye Z, Lamers F, Moser S, Jones PB, Burgess S, Penninx BWJH, Khandaker GM. (2021) Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts . Mol Psychiatry. doi: 10.1038/s41380-021-01188-w  (PubMed)

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Chaplin AB, Smith N, Jones PB, Khandaker GM. (2021) Direction of association between Cardiovascular risk and depressive symptoms during the first 18 years of life: A prospective birth cohort study.  J Affect Disord. 292:508-516. doi: 10.1016/j.jad.2021.05.094.  (PubMed)

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Perry BI, Osimo EF, Upthegrove R, Mallikarjun PK, Yorke J, Stochl J, Perez J, Zammit S, Howes O, Jones PB, Khandaker GM. (2021) Development and external validation of the Psychosis Metabolic Risk Calculator (PsyMetRiC): a cardiometabolic risk prediction algorithm for young people with psychosis. Lancet Psychiatry. 2021 Jul;8(7):589-598. doi: 10.1016/S2215-0366(21)00114-0.  (PubMed)

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Ramsay H, Surcel HM, Björnholm L, Kerkelä M, Khandaker GM, Veijola J. (2021) Associations Between Maternal Prenatal C-Reactive Protein and Risk Factors for Psychosis in Adolescent Offspring: Findings from the Northern Finland Birth Cohort 1986. Schizophr Bull. 2021 Apr 29;47(3):766-775. doi: 10.1093/schbul/sbaa152.  (PubMed)

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Perry BI, Zammit S, Jones PB, Khandaker GM. (2021) Childhood inflammatory markers and risks for psychosis and depression at age 24: Examination of temporality and specificity of association in a population-based prospective birth cohort. Schizophr Res. 230:69-76. doi: 10.1016/j.schres.2021.02.008.  (PubMed)

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Perry BI, Stochl J, Upthegrove R, Zammit S, Wareham N, Langenberg C, Winpenny E, Dunger D, Jones PB, Khandaker GM. (2021) Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations With Risks of Psychosis and Depression in Young Adults. JAMA Psychiatry. 78(4):416-425. doi: 10.1001/jamapsychiatry.2020.4180.  (PubMed)

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Osimo EF, Perry BI, Cardinal RN, Lynall ME, Lewis J, Kudchadkar A, Murray GK, Perez J, Jones PB, Khandaker GM. (2021) Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records.  Brain Behav Immun. 91:117-127. doi: 10.1016/j.bbi.2020.09.011.  (PubMed)

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Stochl J, Jones H, Soneson E, Wagner AP, Khandaker GM, Zammit S, Heron J, Hammerton G, Bullmore ET, Dolan R, Fonagy P, Goodyer IM, Perez J, Jones PB. (2021) Stratification of adolescents across mental phenomena emphasizes the importance of transdiagnostic distress: a replication in two general population cohorts. Eur Child Adolesc Psychiatry. doi: 10.1007/s00787-021-01909-0.  (PubMed)

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Milaneschi Y, Kappelmann N, Ye Z, Lamers F, Moser S, Jones PB, Burgess S, Penninx BWJH, Khandaker GM. (2021) Correction: Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts. Mol Psychiatry. doi: 10.1038/s41380-021-01388-4.  (PubMed)

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Khandaker GM, Zuber V, Rees JMB, Carvalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB, Burgess (2021) Correction: Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort. S.Mol Psychiatry. 26(7):3659-3661. doi: 10.1038/s41380-020-0857-7.  (PubMed)

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Ye Z, Kappelmann N, Moser S, Davey Smith G, Burgess S, Jones PB, Khandaker GM. (2021) Role of inflammation in depression and anxiety: Tests for disorder specificity, linearity and potential causality of association in the UK Biobank . EClinicalMedicine. 38:100992. doi: 10.1016/j.eclinm.2021.100992.  (PubMed)

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Perry BI, Burgess S, Jones HJ, Zammit S, Upthegrove R, Mason AM, Day FR, Langenberg C, Wareham NJ, Jones PB, Khandaker GM. (2021) The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study. PLoS Med. 18(3):e1003455. doi: 10.1371/journal.pmed.1003455.  (PubMed)

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Khandaker GM, Stochl J, Zammit S, Lewis G, Dantzer R, Jones PB. (2021) Association between circulating levels of C-reactive protein and positive and negative symptoms of psychosis in adolescents in a general population birth cohort.  J Psychiatr Res.143:534-542. doi: 10.1016/j.jpsychires.2020.11.028.  (PubMed)

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Osimo EF, Pillinger T, Mateos Rodriguez, I, Khandaker GM, Pariante CM, Howes OD (2020) Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls  Brain Behaviour and Immunity 87:901-909.  (PubMed)

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Parkinson JT, Foley ÉM, Jadon DR, Khandaker GM (2020) Depression in patients with spondyloarthritis: prevalence, incidence, risk factors, mechanisms and management Theraputic advances in musculoskeletal diseas e 12:1759720X20970028.  (PubMed)

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Perry BI, Upthegrove R, Crawford O, Jang S, Lau E, McGill I, Carver E, Jones PB, Khandaker GM (2020) Cardiometabolic risk prediction algorithms for young people with psychosis: a systematic review and exploratory analysis Acta Psychiatricia Scandinavica 142(3):215-232  (PubMed)

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Solmi F, Bulik CM, De Stavola BL, Dalman C, Khandaker GM, Lewis G (2020) Longitudinal associations between circulating interleukin-6 and C-reactive protein in childhood, and eating disorders and disordered eating in adolescence  Brain Behaviour and Immunity 89:491-500  (PubMed)

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Perry BI, Jones HJ, Richardson TG, Zammit S, Wareham NJ, Lewis G, Jones PB, Khandaker GM. (2020) Common mechanisms for type 2 diabetes and psychosis: Findings from a prospective birth cohort Schizophr Res. 223:227-235. doi: 10.1016/j.schres.2020.08.006.  (PubMed)

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Francesconi M, Minichino A, Khandaker GM, Midouhas E, Lewis G, Flouri E. (2020) Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood Schizophr Res. 215:424-429. doi: 10.1016/j.schres.2019.07.035.  (PubMed)

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Lewis G, Dykxhoorn J, Karlsson H, Khandaker GM, Lewis G, Dalman C, Kirkbride JB. (2020) Assessment of the Role of IQ in Associations Between Population Density and Deprivation and Nonaffective Psychosis. JAMA Psychiatry. 77(7):729-736. doi: 10.1001/jamapsychiatry.2020.0103.  (PubMed)

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Perry BI, Oltean BP, Jones PB, Khandaker GM. (2020) Cardiometabolic risk in young adults with depression and evidence of inflammation: A birth cohort study.   Psychoneuroendocrinology. 116:104682. doi: 10.1016/j.psyneuen.2020.104682.  (PubMed)

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Francesconi M, Minichino A, Khandaker GM, Midouhas E, Lewis G, Flouri E. (2020) Reprint of: Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood.  Schizophr Res. 226:24-29. doi: 10.1016/j.schres.  (PubMed)

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Khandaker GM, Zuber V, Rees JMB, Carvalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB, Burgess S. (2020) Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort Mol Psychiatry. 25(7):1477-1486. doi: 10.1038/s41380-019-0395-3.  (PubMed)

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Holland JF, Khandaker GM, Dauvermann MR, Morris D, Zammit S, Donohoe G. (2020) Effects of early life adversity on immune function and cognitive performance: results from the ALSPAC cohort. (PubMed) Soc Psychiatry Psychiatr Epidemiol. 55(6):723-733. doi: 10.1007/s00127-019-01813-8. 

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Solmi F, De Stavola BL, Khandaker GM, Bulik CM, Dalman C, Lewis G. (2020) Association between prenatal maternal infection and disordered eating behaviours in adolescence: a UK population-based prospective birth cohort study. Psychol Med. 50(6):927-935. doi: 10.1017/S0033291719000795.  (PubMed)

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Perry BI, Khandaker GM, Marwaha S, Thompson A, Zammit S, Singh SP, Upthegrove R. (2020) Insulin resistance and obesity, and their association with depression in relatively young people: findings from a large UK birth cohort. Psychol Med. 50(4):556-565. doi: 10.1017/S0033291719000308.  (PubMed)

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Chaplin AB, Jones PB, Khandaker GM. (2020) Association between common early-childhood infection and subsequent depressive symptoms and psychotic experiences in adolescence: a population-based longitudinal birth cohort study. Psychol Med:1-11. doi: 10.1017/S0033291720004080.  (PubMed)  

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Osimo EF, Stochl J, Zammit S, Lewis G, Jones PB, Khandaker GM (2019).  Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort.  Comprehensive Psychiatry  [ PubMed ]

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Khandaker GM (2019).  Commentary: Causal associations between inflammation, cardiometabolic markers and schizophrenia: the known unknowns. International Journal of Epidemiology, 48(5):1516-1518  [ PubMed ]

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Francesconi M, Minichino A, Khandaker GM, Midouhas E, Lewis G, Flouri E (2019).  Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood.  Schizophrenia Research  [ PubMed ]

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Osimo EF, Baxter LJ, Lewis G, Jones PB, Khandaker GM (2019).  Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels.   Psychological Medicine, 49(12):1958-1970  [ PubMed ]

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Khandaker GM (2019).  Early-Life Biomarkers for Psychosis Risk in Young People: Another Nail in the Coffin for Cartesian Dualism.  Biological Psychiatry, 86(1):2-3  [ PubMed ]

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Upthegrove R, Khandaker GM (2019).  Cytokines, Oxidative Stress and Cellular Markers of Inflammation in Schizophrenia.   Current Topics in Behavioural Neuroscience  [ PubMed ]

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Solmi F, De Stavola BL, Khandaker GM, Bulik CM, Dalman C, Lewis G (2019).  Association between prenatal maternal infection and disordered eating behaviours in adolescence: a UK population-based prospective birth cohort study.  Psychological Medicine, 2:1-9  [ PubMed ] 

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Khandaker GM, Zuber V, Rees JMB, Caravalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB, Burgess S (2019).  Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort.  Molecular Psychiatry,  [ PubMed ]

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Perry BI, Khandaker GM, Marwaha S, Thompson A, Zammit S, Singh SP, Upthegrove R (2019).  Insulin resistance and obesity, and their association with depression in relatively young people: findings from a large UK birth cohort.  Psychological Medicine, 11:1-10 [ PubMed ]

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Stochl J, Whittier A, Wagner AP, Veijola J, Jääskeläinen E, Miettunen J, Khandaker GM, Jones PB (2019).  Association between developmental milestones and age of schizophrenia onset: Results from the Northern Finland Birth Cohort 1966.  Schizophrenia Research, 208:228-234  [ PubMed ]

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Stochl J, Soneson E, Wagner AP, Khandaker GM, Goodyer I, Jones PB (2019).  Identifying key targets for interventions to improve psychological wellbeing: replicable results from four UK cohorts.  Psychological Medicine, 49(14):2389-2396  [ PubMed ]

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Chu AL, Stochl J, Lewis G, Zammit S, Jones PB, Khandaker GM (2019).  Longitudinal association between inflammatory markers and specific symptoms of depression in a prospective birth cohort.  Brain Behavior, and Immunity, 76:74-81  [ PubMed ]

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Kappelmann N, Khandaker GM, Dal H, Stochl J, Kosidou K, Jones PB, Dalman C, Karlsson H (2019).  Systemic inflammation and intelligence in early adulthood and subsequent risk of schizophrenia and other non-affective psychoses: a longitudinal cohort and co-relative study.  Psychological Medicine, 49(2):295-302  [ PubMed ]

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Osimo EF, Cardinal RN, Jones PB, Khandaker GM (2018).  Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study.  Psychoneuroendocrinology, 91:226-234  [ PubMed ]

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Filatova S, Koivumaa-Honkanen H, Khandaker GM, Lowry E, Nordström T, Hurtig T, Moilanen K, Miettunen J (2018).  Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966.  Schizophrenia Bulletin, 44(5):1151-1158  [ PubMed ]

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Mackinnon N, Zammit S, Lewis G, Jones PB, Khandaker GM (2018). Association between childhood infection, serum inflammatory markers and intelligence: findings from a population-based prospective birth cohort study. Epidemiology and Infection , 146(2):256-264 [PubMed]

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Khandaker GM, Zammit S, Burgess S, Lewis G, Jones PB (2018). Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort. Brain, Behavior, and Immunity, 69:264-272   [PubMed]

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Khandaker GM, Stochl J, Zammit S, Goodyer I, Lewis G, Jones PB (2018). Childhood inflammatory markers and intelligence as predictors of subsequent persistent depressive symptoms: a longitudinal cohort study. Psychological Medicine , 48(9):1514-1522. [PubMed]

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Khandaker GM, Dantzer R, Jones PB (2017). Immunopsychiatry: important facts. Psychological Medicine , 47(13):2229-2237 [PubMed]

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Filatova S, Koivumaa-Honkanen H, Hirvonen N, Freeman A, Ivandic I, Hurtig T, Khandaker GM, Jones PB, Moilanen K, Miettunen J (2017). Early motor developmental milestones and schizophrenia: A systematic review and meta-analysis. Schizophrenia Research , 188:13-20 [PubMed]

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Khandaker GM, Zammit S, Lewis G, Jones PB (2016). Association between serum C-reactive protein and DSM-IV generalized anxiety disorder in adolescence: Findings from the ALSPAC cohort. Neurobiology of Stress , 4:55-61 [PubMed]

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Khandaker GM, Dantzer R (2016). Is there a role for immune-to-brain communication in schizophrenia? Psychopharmacology, 233(9):1559-1573 [PubMed]

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Zimbron J, Khandaker GM1, Toschi C, Jones PB, Fernandez-Egea E (2016). A systematic review and meta-analysis of randomised controlled trials of treatments for clozapine-induced obesity and metabolic syndrome. European Neuropsychopharmacology, 26(9):1353-65 [PubMed]

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Siebald C, Khandaker GM1, Zammit S, Lewis G, Jones PB (2016). Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study. Comprehensive Psychiatry, 69:45-52 [PubMed]

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Hayes JF, Khandaker GM, Anderson J, Mackay D, Zammit S, Lewis G, Smith DJ, Osborn DP (2016). Childhood interleukin-6, C-reactive protein and atopic disorders as risk factors for hypomanic symptoms in young adulthood: a longitudinal birth cohort study. Psychological Medicine, 47(5):984-986 [PubMed]

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Dibben CR, Khandaker GM, Underwood BR, O'Loughlin C, Keep C, Mann L, Jones PB (2016). First-generation antipsychotics: not gone but forgotten. BJPsych Bulletin, 40(2): 93–96 [PubMed]

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Filatova S, Marttila R, Koivumaa-Honkanen H, Nordström T, Veijola J, Mäki P, Khandaker GM, Isohanni M, Jääskeläinen E, Moilanen K, Miettunen J (2016). A comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the Northern Finland Birth Cohorts 1966 and 1986. Epidemiology and Psychiatry Sciences, 28:1-11 [PubMed]

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Khandaker GM, Dibben CR, Jones PB (2015). Hearing voices: are we getting the message? The British Journal of Psychiatry, 207(3):271-272 [PubMed]

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Stochl J, Jones PB, Perez J, Khandaker GM, Böhnke JR, Croudace TJ (2015). Effects of ignoring clustered data structure in confirmatory factor analysis of ordered polytomous items: a simulation study based on PANSS. International Journal of Methods in Psychiatric Research, 25(3):205-19 [PubMed]

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Khandaker GM, Stochl J, Zammit S, Lewis G, Jones PB (2015). A population-based prospective birth cohort study of childhood neurocognitive and psychological functioning in healthy survivors of early life meningitis. Annals of Epidemiology, 25(4):236-42 [PubMed]

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Stochl J, Khandaker GM, Lewis G, Perez J, Goodyer IM, Zammit S, Sullivan S, Croudace TJ, Jones PB (2015). Mood, anxiety and psychotic phenomena measure a common psychopathological factor. Psychological Medicine, 45(7):1483-93 [PubMed]

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Khandaker GM, Stochl J, Zammit S, Lewis G, Jones PB (2014), A population-based longitudinal study of childhood neurodevelopmental disorders, IQ and subsequent risk of psychotic experiences in adolescence. Psychological Medicine , 1-10 [PubMed]

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Khandaker GM, Stochl J, Zammit S, Lewis G, Jones PB (2014), Childhood epstein-barr virus infection and subsequent risk of psychotic experiences in adolescence: a population-based prospective serological study. Schizophrenia Research, 158(1-3):19-24 [PubMed]

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Khandaker GM, Zammit S, Lewis G, Jones PB (2014), A population-based study of atopic disorders and inflammatory markers in childhood before psychotic experiences in adolescence. Schizophrenia Research, 152(1):139-45 [PubMed]

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Khandaker GM, Zimbron J, Lewis G, Jones PB (2013). Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies. Psychological Medicine, 43(2):239-57 [PubMed]

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Zimbrón J, Ruiz de Azúa S, Khandaker GM, Gandamaneni PK, Crane CM, González-Pinto A, Stochl J, Jones PB, Pérez J (2013), Clinical and sociodemographic comparison of people at high-risk for psychosis and with first-episode psychosis. Acta Psychiatrica Scandinavica, 127(3):210-6 [PubMed]

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Khandaker GM, Gandamaneni PK, Dibben CR, Cherukuru S, Cairns P, Ray MK (2013), Evaluating care pathways for community psychiatry in England: a qualitative study. Journal of Evaluation in Clinical Practice, 19(2):298-303 [PubMed]

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Khandaker GM, Kirkbride JB, Jones PB (2012), Epidemiological challenges in systematic reviews. The British Journal of Psychiatry, 201(3):248 [PubMed]

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Khandaker GM, Zimbron J, Dalman C, Lewis G, Jones PB (2012), Childhood infection and adult schizophrenia: a meta-analysis of population-based studies. Schizophrenia Research, 139(1-3):161-8 [PubMed]

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Khandaker GM, Dibben CR, Jones PB (2012), Does maternal body mass index during pregnancy influence risk of schizophrenia in the adult offspring? Obesity Review, 13(6):518-27 [PubMed]

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Khandaker GM, Dibben CR, Jones PB (2012). Prenatal maternal influenza and schizophrenia in offspring: what does this tell us about fetal programming of chronic disease? Journal of Pediatric Infectious Diseases, 7(2): 81-68 [Link]

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Khandaker GM, Barnett JH, White IR, Jones PB (2011). A quantitative meta-analysis of population-based studies of premorbid intelligence and schizophrenia. Schizophrenia Research, 132(2-3):220-7 [PubMed]

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Khandaker GM, Jones PB (2011), Cognitive and functional impairment after severe sepsis. The Journal of the American Medical Association, 305(7):673-4; author reply 674 [PubMed]

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Khandaker GM, Dibben C, Zurynski Y, Elliott EJ, Booy R (2010), Mania in a patient with H1N1: is oseltamivir the culprit or a red herring? The American Journal of Psychiatry, 167(9):1129-30; author reply 1130 [PubMed]

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Dibben C, Khandaker G, Ramana R (2009), Aftercare under Section 117 of the Mental Health Act 1983: awareness and practice. Medicine, Science and the Law 49(1):41-5 [PubMed]

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Khandaker GM, Cherukuru S, Dibben C, Ray MK. (2009), From sector-based to a functional model: a qualitative study of staff perception. BJPsych Bulletin (Formerly The Psychiatrist and Psychiatric Bulletin), 33:329-332 [Link]

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Dibben C, Saeed H, Stagias K, Khandaker GM, Rubinsztein J. (2008), Impact of a Crisis Resolution and Home Treatment Team (CRHTT) for older people with mental illness. BJPsych Bulletin (Formerly The Psychiatrist and Psychiatric Bulletin), 32:268-270 [Link]