Neuroinflammation and Schizophrenia. Edited by GM Khandaker, U Meyer and PB Jones. Springer

Immunopsychiatry: An Introduction. Edited by GM Khandaker, N Harrison, R Dantzer, ET Bullmore. Cambridge University Press (in progress)

Book Chapters


Khandaker GM (2016). Inflammation and immunity in schizophrenia and related psychotic disorders: an overview of clinical research. In Primer of Psychoneuroimmunology Research, Edited by Mark Opp. Psychoneuroimmunology Research Society. [Link]

Khandaker GM, Clarke M, Cannon M, Jones PB (2013). Life course approach to schizophrenia and related psychosis. In Life Course Epidemiology of Mental Disorders. Edited by Karestan Koenen, Sasha Rudenstine, Ezra Susser, and Sandro Galea. Oxford University Press. [Link]

Research Articles

Key Publications

Khandaker GM, Oltean BP, Kaser M, Dibben CRM, Ramana R, Jadon, DR, Dantzer R, Coles AJ, Lewis G, Jones PB (2018). Protocol for the insight study: a randomised controlled trial of single- dose tocilizumab in patients with depression and low-grade inflammation. BMJ Open, 8:1-9 [PubMed]

Khandaker GM, Dalman C, Kappelmann N, Stochl J, Dal H, Kosidou K, Jones PB, Karlsson H (2018). Association of childhood infection with IQ and adult nonaffective psychosis in swedish men: a population-based longitudinal cohort and co-relative study. JAMA Psychiatry, 75(4):356-362 [PubMed]

Kappelmann N, Lewis G, Dantzer R, Jones PB, Khandaker GM (2018). Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Molecular Psychiatry,23(2):335-343 [PubMed]

Khandaker, GM, Cousins L, Deakin J, Lennox BR, Yolken R, Jones PB (2015), Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment. The Lancet Psychiatry, 2(3):258-270 [PubMed]

Khandaker GM, Zammit S, Lewis G, Jones PB (2014). Association of serum Interleukin 6 and C-Reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study. JAMA Psychiatry, 71(10):1121-8 [PubMed]

All Publications

Osimo EF, Stochl J, Zammit S, Lewis G, Jones PB, Khandaker GM (2019). Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort. Comprehensive Psychiatry [PubMed]

Khandaker GM (2019). Commentary: Causal associations between inflammation, cardiometabolic markers and schizophrenia: the known unknowns. International Journal of Epidemiology, 48(5):1516-1518 [PubMed]

Francesconi M, Minichino A, Khandaker GM, Midouhas E, Lewis G, Flouri E (2019). Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood. Schizophrenia Research [PubMed]

Osimo EF, Baxter LJ, Lewis G, Jones PB, Khandaker GM (2019). Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels. Psychological Medicine, 49(12):1958-1970 [PubMed]

Khandaker GM (2019). Early-Life Biomarkers for Psychosis Risk in Young People: Another Nail in the Coffin for Cartesian Dualism. Biological Psychiatry, 86(1):2-3 [PubMed]

Upthegrove R, Khandaker GM (2019). Cytokines, Oxidative Stress and Cellular Markers of Inflammation in Schizophrenia. Current Topics in Behavioural Neuroscience [PubMed]

Solmi F, De Stavola BL, Khandaker GM, Bulik CM, Dalman C, Lewis G (2019). Association between prenatal maternal infection and disordered eating behaviours in adolescence: a UK population-based prospective birth cohort study. Psychological Medicine, 2:1-9 [PubMed

Khandaker GM, Zuber V, Rees JMB, Caravalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB, Burgess S (2019). Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort. Molecular Psychiatry, [PubMed]

Perry BI, Khandaker GM, Marwaha S, Thompson A, Zammit S, Singh SP, Upthegrove R (2019). Insulin resistance and obesity, and their association with depression in relatively young people: findings from a large UK birth cohort. Psychological Medicine, 11:1-10 [PubMed]

Stochl J, Whittier A, Wagner AP, Veijola J, Jääskeläinen E, Miettunen J, Khandaker GM, Jones PB (2019). Association between developmental milestones and age of schizophrenia onset: Results from the Northern Finland Birth Cohort 1966. Schizophrenia Research, 208:228-234 [PubMed]

Stochl J, Soneson E, Wagner AP, Khandaker GM, Goodyer I, Jones PB (2019). Identifying key targets for interventions to improve psychological wellbeing: replicable results from four UK cohorts. Psychological Medicine, 49(14):2389-2396 [PubMed]

Chu AL, Stochl J, Lewis G, Zammit S, Jones PB, Khandaker GM (2019). Longitudinal association between inflammatory markers and specific symptoms of depression in a prospective birth cohort. Brain Behavior, and Immunity, 76:74-81 [PubMed]

Kappelmann N, Khandaker GM, Dal H, Stochl J, Kosidou K, Jones PB, Dalman C, Karlsson H (2019). Systemic inflammation and intelligence in early adulthood and subsequent risk of schizophrenia and other non-affective psychoses: a longitudinal cohort and co-relative study. Psychological Medicine, 49(2):295-302 [PubMed]

Osimo EF, Cardinal RN, Jones PB, Khandaker GM (2018). Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study. Psychoneuroendocrinology, 91:226-234 [PubMed]

Filatova S, Koivumaa-Honkanen H, Khandaker GM, Lowry E, Nordström T, Hurtig T, Moilanen K, Miettunen J (2018). Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966. Schizophrenia Bulletin, 44(5):1151-1158 [PubMed]

Mackinnon N, Zammit S, Lewis G, Jones PB, Khandaker GM (2018). Association between childhood infection, serum inflammatory markers and intelligence: findings from a population-based prospective birth cohort study. Epidemiology and Infection , 146(2):256-264 [PubMed]

Khandaker GM, Zammit S, Burgess S, Lewis G, Jones PB (2018). Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort. Brain, Behavior, and Immunity, 69:264-272 [PubMed]

Khandaker GM, Stochl J, Zammit S, Goodyer I, Lewis G, Jones PB (2018). Childhood inflammatory markers and intelligence as predictors of subsequent persistent depressive symptoms: a longitudinal cohort study. Psychological Medicine, 48(9):1514-1522. [PubMed]

Khandaker GM, Dantzer R, Jones PB (2017). Immunopsychiatry: important facts. Psychological Medicine, 47(13):2229-2237 [PubMed]

Filatova S, Koivumaa-Honkanen H, Hirvonen N, Freeman A, Ivandic I, Hurtig T, Khandaker GM, Jones PB, Moilanen K, Miettunen J (2017). Early motor developmental milestones and schizophrenia: A systematic review and meta-analysis. Schizophrenia Research, 188:13-20 [PubMed]

Metcalf SA, Jones, PB, Nordstrom, T, Timonen, M, Mäki, P, Miettunen, J., ... & Khandaker GM (2017). Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: A prospective birth cohort study. Brain, Behavior, and Immunity, 59:253-259. [PubMed]

Khandaker GM, Zammit S, Lewis G, Jones PB (2016). Association between serum C-reactive protein and DSM-IV generalized anxiety disorder in adolescence: Findings from the ALSPAC cohort. Neurobiology of Stress, 4:55-61 [PubMed]

Khandaker GM, Dantzer R (2016). Is there a role for immune-to-brain communication in schizophrenia? Psychopharmacology, 233(9):1559-1573 [PubMed]

Zimbron J, Khandaker GM1, Toschi C, Jones PB, Fernandez-Egea E (2016). A systematic review and meta-analysis of randomised controlled trials of treatments for clozapine-induced obesity and metabolic syndrome. European Neuropsychopharmacology, 26(9):1353-65 [PubMed]

Siebald C, Khandaker GM1, Zammit S, Lewis G, Jones PB (2016). Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study. Comprehensive Psychiatry, 69:45-52 [PubMed]

Hayes JF, Khandaker GM, Anderson J, Mackay D, Zammit S, Lewis G, Smith DJ, Osborn DP (2016). Childhood interleukin-6, C-reactive protein and atopic disorders as risk factors for hypomanic symptoms in young adulthood: a longitudinal birth cohort study. Psychological Medicine, 47(5):984-986 [PubMed]

Dibben CR, Khandaker GM, Underwood BR, O'Loughlin C, Keep C, Mann L, Jones PB (2016). First-generation antipsychotics: not gone but forgotten. BJPsych Bulletin, 40(2): 93–96 [PubMed]

Filatova S, Marttila R, Koivumaa-Honkanen H, Nordström T, Veijola J, Mäki P, Khandaker GM, Isohanni M, Jääskeläinen E, Moilanen K, Miettunen J (2016). A comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the Northern Finland Birth Cohorts 1966 and 1986. Epidemiology and Psychiatry Sciences, 28:1-11 [PubMed]

Khandaker GM, Dibben CR, Jones PB (2015). Hearing voices: are we getting the message? The British Journal of Psychiatry, 207(3):271-272 [PubMed]

Stochl J, Jones PB, Perez J, Khandaker GM, Böhnke JR, Croudace TJ (2015). Effects of ignoring clustered data structure in confirmatory factor analysis of ordered polytomous items: a simulation study based on PANSS. International Journal of Methods in Psychiatric Research, 25(3):205-19 [PubMed]

Khandaker GM, Stochl J, Zammit S, Lewis G, Jones PB (2015). A population-based prospective birth cohort study of childhood neurocognitive and psychological functioning in healthy survivors of early life meningitis. Annals of Epidemiology, 25(4):236-42 [PubMed]

Stochl J, Khandaker GM, Lewis G, Perez J, Goodyer IM, Zammit S, Sullivan S, Croudace TJ, Jones PB (2015). Mood, anxiety and psychotic phenomena measure a common psychopathological factor. Psychological Medicine, 45(7):1483-93 [PubMed]

Khandaker GM, Stochl J, Zammit S, Lewis G, Jones PB (2014), A population-based longitudinal study of childhood neurodevelopmental disorders, IQ and subsequent risk of psychotic experiences in adolescence. Psychological Medicine, 1-10 [PubMed]

Khandaker GM, Stochl J, Zammit S, Lewis G, Jones PB (2014), Childhood epstein-barr virus infection and subsequent risk of psychotic experiences in adolescence: a population-based prospective serological study. Schizophrenia Research, 158(1-3):19-24 [PubMed]

Khandaker GM, Zammit S, Lewis G, Jones PB (2014), A population-based study of atopic disorders and inflammatory markers in childhood before psychotic experiences in adolescence. Schizophrenia Research, 152(1):139-45 [PubMed]

Khandaker GM, Zimbron J, Lewis G, Jones PB (2013). Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies. Psychological Medicine, 43(2):239-57 [PubMed]

Zimbrón J, Ruiz de Azúa S, Khandaker GM, Gandamaneni PK, Crane CM, González-Pinto A, Stochl J, Jones PB, Pérez J (2013), Clinical and sociodemographic comparison of people at high-risk for psychosis and with first-episode psychosis. Acta Psychiatrica Scandinavica, 127(3):210-6 [PubMed]

Khandaker GM, Gandamaneni PK, Dibben CR, Cherukuru S, Cairns P, Ray MK (2013), Evaluating care pathways for community psychiatry in England: a qualitative study. Journal of Evaluation in Clinical Practice, 19(2):298-303 [PubMed]

Khandaker GM, Kirkbride JB, Jones PB (2012), Epidemiological challenges in systematic reviews. The British Journal of Psychiatry, 201(3):248 [PubMed]

Khandaker GM, Zimbron J, Dalman C, Lewis G, Jones PB (2012), Childhood infection and adult schizophrenia: a meta-analysis of population-based studies. Schizophrenia Research, 139(1-3):161-8 [PubMed]

Khandaker GM, Dibben CR, Jones PB (2012), Does maternal body mass index during pregnancy influence risk of schizophrenia in the adult offspring? Obesity Review, 13(6):518-27 [PubMed]

Khandaker GM, Dibben CR, Jones PB (2012). Prenatal maternal influenza and schizophrenia in offspring: what does this tell us about fetal programming of chronic disease? Journal of Pediatric Infectious Diseases, 7(2): 81-68 [Link]

Khandaker GM, Barnett JH, White IR, Jones PB (2011). A quantitative meta-analysis of population-based studies of premorbid intelligence and schizophrenia. Schizophrenia Research, 132(2-3):220-7 [PubMed]

Khandaker GM, Jones PB (2011), Cognitive and functional impairment after severe sepsis. The Journal of the American Medical Association, 305(7):673-4; author reply 674 [PubMed]

Khandaker GM, Dibben C, Zurynski Y, Elliott EJ, Booy R (2010), Mania in a patient with H1N1: is oseltamivir the culprit or a red herring? The American Journal of Psychiatry, 167(9):1129-30; author reply 1130 [PubMed]

Dibben C, Khandaker G, Ramana R (2009), Aftercare under Section 117 of the Mental Health Act 1983: awareness and practice. Medicine, Science and the Law 49(1):41-5 [PubMed]

Khandaker GM, Cherukuru S, Dibben C, Ray MK. (2009), From sector-based to a functional model: a qualitative study of staff perception. BJPsych Bulletin (Formerly The Psychiatrist and Psychiatric Bulletin), 33:329-332 [Link]

Dibben C, Saeed H, Stagias K, Khandaker GM, Rubinsztein J. (2008), Impact of a Crisis Resolution and Home Treatment Team (CRHTT) for older people with mental illness. BJPsych Bulletin (Formerly The Psychiatrist and Psychiatric Bulletin), 32:268-270 [Link]

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