Welcome to the Inflammation and Psychiatry (InPsych) Research Group, University of Cambridge

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About InPsych

The Inflammation and Psychiatry (InPsych) Research group is led by Dr Golam Khandaker at the Department of Psychiatry, University of Cambridge School of Clinical Medicine. The group uses population-based epidemiological, clinical and treatment studies to investigate the links between immune system and neuropsychiatric brain disorders particularly depression and schizophrenia.

The aim of the work is to identify novel mechanisms and treatments for depression and schizophrenia that affect about one in four people in lifetime. This work is clinically important because about a third of those who are affected by these illnesses do not respond to currently available treatments.

Research Projects

Funded by the Wellcome Trust, the InPsych group is currently investigating the role of low-grade inflammation, particularly IL-6 and other circulating inflammatory markers, in pathogenesis of depression and schizophrenia.

The Insight Study

Effect of IL-6 inhibition in inflamed depression

Mendalian Randomisation Study

Causal relationships between IL-6/IL-6R pathways, depression and schizophrenia

Research Overview

Current research in the InPsych group is focused on the role of low-grade inflammation (cytokines, genes and peripheral immune cells) in depression and schizophrenia. We use epidemiological population-based cohort studies to examine causes and psychiatric consequences of inflammation. Identifying early-life predictors of illness is helpful for developing appropriate strategies for prevention, early detection and intervention.

We use clinical studies to gain a better understanding of psychiatric patients who display evidence of low-grade inflammation. We use clinical trials to examine the effect of immune-modulating drugs on cognition, mood and psychosis. This work may help to inform a more personalised approach to treatment of major psychiatric disorders.

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Featured News

Anti-inflammatory drugs might someday treat depression

October 18, 2016

In the future, a new class of anti-inflammatory drugs could be used to treat depression, say University of Cambridge researchers.

A New Key to Understanding Depression

August 14, 2014

Scientists are studying alternative explanations for complicated conditions like depression, and researchers from the University of Cambridge are...

The Team

InPsych is a research group with bright ideas and talented staff. We welcome queries from prospective PhD students, staff and interns. To find out more about group members click below.

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Notable publications from the InPsych group have appeared in JAMA Psychiatry, Molecular Psychiatry and The Lancet Psychiatry.


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The InPsych group has longstanding collaborations with researchers in the UK, rest of Europe and USA, and with population-based cohorts from the UK and abroad.

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Contact Us

We are happy to hear from prospective group members, research collaborators, participants, media, patients and others. Email: info@immunopsychiatry.com

Our address

Department of Psychiatry
University of Cambridge
Herchel Smith Building for Brain and Mind Sciences
Cambridge Biomedical Campus
Cambridge, CB2 0SZ, UK

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